A facile two-step synthesis of 2-arylbenzofurans based on the selective cross McMurry couplings

XF Duan, J Zeng, ZB Zhang, GF Zi

Index: Duan, Xin-Fang; Zeng, Jing; Lue, Jia-Wei; Zhang, Zhan-Bin Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9873 - 9876

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Citation Number: 84

Abstract

A novel two-step synthesis of 2-arylbenzofurans has been developed. It involves a selective cross McMurry coupling of a salicylaldehyde or substituted salicylaldehyde with an aromatic aldehyde and a sequential oxidative cyclization of the resulting ortho-vinylphenols. Utilizing this synthetic protocol, a variety of 2-arylbenzofurans including cicerfuran (5) have been efficiently synthesized.

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