A practical approach for spiro??and 5??monoalkylated barbituric acids

P Singh, K Paul

Index: Singh, Palwinder; Paul, Kamaldeep Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 3 p. 607 - 612

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Citation Number: 21

Abstract

The single step reactions of N, N'-substituted/-unsubstituted barbituric acids with various alkyl dihalides under phase transfer catalytic conditions using DMF–K2CO3(base), TBAHSO4 (catalyst) provide spirobarbituric acids in moderate to high yields. Irrespective of the existence of C5-monoalkylated compounds in the enolic form (confirmed by the isolation of some of its analogues), the second alkylation predominantly takes place at C5. The ...