Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: Extending towards the β-exosite

…, D Caglič, P Čapek, Y Zhang, S Godbole…

Index: Smith, Garry R.; Caglic, Dejan; Capek, Petr; Zhang, Yan; Godbole, Sujata; Reitz, Allen B.; Dickerson, Tobin J. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3754 - 3757

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Citation Number: 8

Abstract

Botulinum neurotoxins (BoNTs) are the most toxic proteins known to man, exposure to which results in flaccid paralysis. Given their extreme potency, these proteins have become studied as possible weapons of bioterrorism; however, effective treatments that function after intoxication have not progressed to the clinic. Here, we have reexamined one of the most effective inhibitors, 2, 4-dichlorocinnamyl hydroxamate, in the context of the known ...