Peptide research 1991-01-01

Semiautomated T-bag peptide synthesis using 9-fluorenyl-methoxycarbonyl strategy and benzotriazol-1-yl-tetramethyl-uronium tetrafluoroborate activation.

A G Beck-Sickinger, H Dürr, G Jung

Index: Pept. Res. 4(2) , 88-94, (1991)

Full Text: HTML

Abstract

Multiple peptide synthesis using the T-bag method is considerably facilitated using 9-fluorenyl-methoxycarbonyl strategy and benzotriazol-1-yl-tetramethyl-uronium tetrafluoroborate activation. Convenient protocols were achieved when semiautomation was applied. Successful syntheses of analogues of neuropeptide Y demonstrate the advantages of these improvements. Various peptides consisting of up to eighteen residues were built up with unusual amino acid residues. Useful hints are given for semiautomated multiple peptide synthesis for up to 120 different peptides.

Related Compounds

  • TBTU

Related Articles:

Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents.

2008-09-01

[Antimicrob. Agents Chemother. 52 , 3229-36, (2008)]

S. Zimmer et al., C.H. Schneider and A.N. Eberle, eds.

[Proc. 22nd Eur. Pept. Symp.: Peptides 1992 Leiden 1993, p. 393]

O-(BENZOTRIAZOL-1-YL)-N, N, N', N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE (TBTU): A NEW REAGENT FOR THE CLEAVAGE OF TETRAHYDROPYRANYL, SILYL AND 4, 4'-D IMETHOXYTRITYL ETHERS. Ramasamy KS and Averett D.

[Synlett 6 , 709-712, (1999)]

I. Abdelmoty

[Lett. Pept. Sci. 1 , 57, (1994)]

Automated solid-phase peptide synthesis: use of 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate for coupling of tert-butyloxycarbonyl amino acids.

1992-02-01

[Anal. Biochem. 200(2) , 301-9, (1992)]

More Articles...