Chemical Communications

Synthesis of para-methoxybenzyl (PMB) ethers under neutral conditions

EO Nwoye, GB Dudley

Index: Nwoye, Ernest O.; Dudley, Gregory B. Chemical Communications, 2007 , # 14 p. 1436 - 1437

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Citation Number: 23

Abstract

As shown in Table 1, the formation of PMB ethers using 1 and methyl triflate occurs efficiently on a range of alcohols (depicted in Fig. 2). The presence of magnesium oxide (MgO) provides for higher yields and easier purification of 3. N-Methyl-lepidone (10) is the expected by-product of this reaction; bis-PMB ether 11, presumably derived from adventitious moisture and/or reaction with magnesium oxide, is also observed in varying amounts. ... Fig. 2 Substrates and ...

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