Synthesis, antitumor activity, and chemical properties of silaplatin and related platinum (II) and platinum (IV) complexes derived from. beta.-silyl amines

WK Anderson, R Kasliwal, DM Houston…

Index: Anderson, Wayne K.; Kasliwal, Ravindra; Houston, D. Michael; Wang, Yueh-sha; Narayanan, Ven L.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 19 p. 3789 - 3797

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Citation Number: 29

Abstract

Platinum (11) and platinum (IV) coordination complexes derived from P-silyl-substituted amines were prepared. The solubility of selected complexes in water and physiological saline was measured, and the effect of the, &silicon on the reactivity of the complex in aqueous solution was determined by HPLC. The stabilities of selected silyl complexes were compared to the carbon analogues. The cyclic complexes 2a (“silaplatin”) and its Pt (IV) ...