[Significance of morphofunctional assessment of tissue basophil reactions in prognostication of harmful effects of chemical substances].

V V Iaglov, N I Sheina, M A Fesenko

Index: Gig. Tr. Prof. Zabol. (5) , 23-5, (1991)

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Abstract

The article contains a comparative analysis of experimental data on the assessment of the general toxicological, gonadotrophic effects and morphofunctional reactions of tissue basophils under the influence of 4-bromine-o-xylene, carbon disulfide and pyracryl. Established was the gonadotrophic action of pyracryl against the growing activity of tissue basophils manifested through increased infiltration and high-level degranulation in female rats' reproductive organs. Demonstrated was that, under the influence of low-intensity chemical factors, tissue basophils morphofunctional reactions were those of organ-related nature. The quantitative assessment of tissue basophils was proposed as an informative model for studies of selective (gonadotrophic) actions of low-intensity chemical substances.