Tetrahedron

Water-soluble calixarenes as new inverse phase-transfer catalysts. Their application to aldol-type condensation and Michael addition reactions in water

S Shimizu, S Shirakawa, T Suzuki, Y Sasaki

Index: Shimizu, Shoichi; Shirakawa, Seiji; Suzuki, Takashi; Sasaki, Yasuyuki Tetrahedron, 2001 , vol. 57, # 29 p. 6169 - 6173

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Citation Number: 60

Abstract

Aldol-type condensation and Michael addition reactions of activated methyl and methylene compounds in aqueous NaOH solution have been developed without the need for any added organic solvents. The water-soluble calix [n] arenes, which contain trimethylammoniomethyl groups on the upper rim, were used as inverse phase-transfer catalysts, resulting in the corresponding products in good to excellent yields.