Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 1986-02-01

Isolation, identification and bacterial mutagenicity of 2-nitro-9-fluorenone from diesel-exhaust particle extracts.

W E Bechtold, T R Henderson, A L Brooks

Index: Mutat. Res. 173(2) , 105-9, (1986)

Full Text: HTML

Abstract

Organic extracts of diesel-exhaust particles show direct mutagenic activity in the Salmonella typhimurium bacterial mutagenicity assay. Nitro-aromatic compounds are believed to be responsible for part of the mutagenicity. A previously unidentified polyfunctional nitro-aromatic compound, 2-nitro-9-fluorenone (2N-Fone) was isolated from diesel-exhaust particles using a two-step fractionation scheme consisting of Sephadex LH20 chromatography and silica-gel thin-layer chromatography. Positive identification was by gas chromatography/mass spectroscopy and coelution with an authentic standard. Direct and indirect mutagenicities of 2N-Fone in several bacterial strains were also determined. The results indicated that 2N-Fone produces 60-70 rev/nmole of direct mutagenic activity, and is about 1/5 to 1/10 as mutagenic as 1-nitropyrene.

Related Compounds

  • 2-Nitro-9-fluoreno...

Related Articles:

Laser desorption/ionization time-of-flight mass spectrometry of nitrated polycyclic aromatic hydrocarbons.

1996-07-15

[Anal. Chem. 68(14) , 2319-24, (1996)]

2-Nitrofluorene and related compounds: prevalence and biological effects.

1988-09-01

[Mutat. Res. 196(2) , 177-209, (1988)]

Voltammetric Determination of Genotoxic Nitro Derivatives of Fluorene and 9-Fluorenone Using a Mercury Meniscus Modified Silver Solid Amalgam Electrode. Vyskocil V, et al.

[Electroanalysis 22(17-18) , 2034-2042, (2010)]

2-Nitrofluoren-9-one: a unique mutagen formed in the photo-oxidation of 2-aminofluorene.

1986-03-01

[Carcinogenesis 7(3) , 499-502, (1986)]

In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions.

2006-11-01

[J. Pharm. Pharmacol. 58(11) , 1545-52, (2006)]

More Articles...