Preparation of Alkyl and Aryl Chlorodifluoromethyl Ethers Using BrF3

Y Hagooly, R Sasson, MJ Welch…

Index: Hagooly, Youlia; Sasson, Revital; Welch, Michael J.; Rozen, Shlomo European Journal of Organic Chemistry, 2008 , # 17 p. 2875 - 2880

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Citation Number: 6

Abstract

Abstract Both alkyl and aryl chlorothioformates could readily be obtained from the corresponding alcohols and thiophosgene. These families of compounds were treated with BrF 3 to form the corresponding alkyl and aryl chlorodifluoromethyl ethers in 60–85% yields. The method is suitable for constructing a variety of aliphatic as well as electron-deficient aromatic chlorodifluoromethyl ethers. The reactions proceed under mild conditions and ...