Bollettino chimico farmaceutico 1995-05-01

[Pharmacologic profile of n-palmitoylglycine. Its effect on reserpine and haloperidol catalepsy].

A Vamvakidès

Index: Boll. Chim. Farm. 134(5) , 258-62, (1995)

Full Text: HTML

Abstract

N-palmitoyl glycine (PG), synthesized by the mixed anhydrides method, displayed nootropic effects (in the "step-down" test) as well as an anti-immobility action in the forced swimming test, in mice. However no anticonvulsant effects were obtained, even at high dose (300 mg/Kg, po), in the maximal electroshock or against the convulsions induced by pentetrazol. In the study reported in this paper PG potentiated the reserpine or the haloperidol catalepsy in rats. The potentiation of the haloperidol catalepsy was antagonized by imipramine which displayed antiglutamatergic and antimuscarinic properties. On the other hand at 150 mg/Kg (ip), a dose which potentiated the haloperidol catalepsy, PG stimulated the dopaminergic function in the striatum. These results could therefore constitute a first clue suggesting a stimulation, by PG, of the cholinergic and GABAergic interneurons, by glycinergic potentiation of the NMDA receptors in the striatum.

Related Compounds

  • PALGLY

Related Articles:

¹H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet.

2015-01-01

[PLoS ONE 10(3) , e0120950, (2015)]

GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.

2013-01-01

[PLoS ONE 8 , e60314, (2013)]

Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells.

2016-05-01

[J. Lipid Res. 57 , 781-90, (2016)]

Effects of feeding Spodoptera littoralis on lima bean leaves. I. Membrane potentials, intracellular calcium variations, oral secretions, and regurgitate components.

2004-04-01

[Plant Physiol. 134(4) , 1752-62, (2004)]

Novel endogenous N-acyl glycines identification and characterization.

2012-01-01

[Vitam. Horm. 81 , 191-205, (2009)]

More Articles...