International Journal of Pharmaceutics 2015-01-01

Vancomycin-modified silica: Synthesis, controlled release and biological activity of the drug.

Joanna Kurczewska, Paulina Sawicka, Magdalena Ratajczak, Marzena Gajęcka, Grzegorz Schroeder

Index: Int. J. Pharm. 486 , 226-31, (2015)

Full Text: HTML

Abstract

Vancomycin was immobilized on three different organically functionalized silicas. The materials obtained were used for a controlled release of the antibiotic. The influence of the type of chemical bond on the in vitro drug release was investigated. A weak ionic bonding caused burst release of the drug within one day. A covalent bonding resulted in a slowdown in the release process and uniformity of dosage release. For these two carriers, biological activity of the drug was retained because the minimal inhibitory concentration values against the strains tested were similar to that of a free form of the drug (about 2 μg/mL). A strong ionic bonding of vancomycin adversely affected both the drug release, as well as its biological activity. A strong base on the surface of the silica prevented disconnection of the antibiotic which then became ineffective.Copyright © 2015 Elsevier B.V. All rights reserved.

Related Compounds

  • Propanoyl chloride

Related Articles:

Remarkably regioselective deacylation of cellulose esters using tetraalkylammonium salts of the strongly basic hydroxide ion.

2014-10-13

[Carbohydr. Polym. 111 , 25-32, (2014)]

Use of multivariate statistical techniques to optimize the separation of 17 capsinoids by ultra performance liquid chromatography using different columns.

2015-03-01

[Talanta 134 , 256-63, (2015)]

Synthesis and pharmacological evaluation of carvacrol propionate.

2014-10-01

[Inflammation 37(5) , 1575-87, (2014)]

Pyrazolone incorporating bipyridyl metallointercalators as effective DNA, protein and lung cancer targets: Synthesis, characterization and in vitro biocidal evaluation.

2015-10-05

[Chem. Biol. Interact. 240 , 250-66, (2015)]

(-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors.

2000-08-01

[Nucl. Med. Biol. 27(6) , 533-9, (2000)]

More Articles...