FEBS Letters 1985-10-14

Regulation of pantothenate kinase from various tissues of the rat.

M N Fisher, J R Neely

Index: FEBS Lett. 190(2) , 293-6, (1985)

Full Text: HTML

Abstract

The relative tissue activities of pantothenate kinase range from 1 to 5 nmol . min-1 . g-1 wet wt for heart, brain, kidney, and liver. The enzyme partially purified from each tissue is inhibited by CoA, but there is a 10-fold greater potency of inhibition of the heart enzyme compared to those from the other tissues. With the heart and liver enzyme, this difference in potency of CoA inhibition may be a reflection of the differing cytosolic CoA concentrations in these tissues. L-Carnitine specifically reversed the inhibition of each enzyme by CoA. It is concluded that L-carnitine may be a regulator of CoA synthesis in each tissue.

Related Compounds

  • dowex 1x4-200 ion-...

Related Articles:

On-line preconcentration of mercury by sorption on an anion-exchange resin loaded with 1,5-bis[(2-pyridyl)-3-sulphophenyl methylene] thiocarbonohydrazide and determination by cold-vapour inductively coupled plasma atomic emission.

1998-08-01

[Talanta 46 , 1095-1105, (1998)]

On-line ion-exchange preconcentration and determination of traces of platinum by electrothermal atomic absorption spectrometry.

2003-04-01

[Anal. Bioanal. Chem 375 , 1229-1233, (2003)]

On-line preconcentration of rhodium on an anion-exchange resin loaded with 1,5-bis(2-pyridyl)-3-sulphophenyl methylene thiocarbonohydrazide and its determination in environmental samples.

2004-09-08

[Talanta 64 , 230-236, (2004)]

Synthesis of new hypoxia markers EF1 and [18F]-EF1.

1999-12-01

[Appl. Radiat. Isot. 51(6) , 643-50, (1999)]

Borate complexes of x-ray iodinated contrast agents: characterization and sorption studies for their removal from aqueous media.

2012-02-29

[J. Hazard. Mater. 205-206 , 10-16, (2012)]

More Articles...