Organic & biomolecular chemistry

Silver-catalyzed amidation of benzoylformic acids with tertiary amines via selective carbon–nitrogen bond cleavage

X Zhang, W Yang, L Wang

Index: Zhang, Xiaobin; Yang, Wenchao; Wang, Lei Organic and Biomolecular Chemistry, 2013 , vol. 11, # 22 p. 3649 - 3654

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Citation Number: 29

Abstract

A novel approach towards the synthesis of α-ketoamides using tertiary amines as nitrogen group sources via C–N bond cleavage has been developed. In the presence of Ag 2 CO 3 and K 2 S 2 O 8, α-keto acids reacted with tertiary amines to afford the corresponding α- ketoamides in good yields.

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