Reactions of synthetic [2Fe-2S] and [4Fe-4S] clusters with nitric oxide and nitrosothiols

…, ZJ Tonzetich, E Reisner, SJ Lippard

Index: Harrop, Todd C.; Tonzetich, Zachary J.; Reisner, Erwin; Lippard, Stephen J. Journal of the American Chemical Society, 2008 , vol. 130, # 46 p. 15602 - 15610

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Citation Number: 76

Abstract

The interaction of nitric oxide (NO) with iron− sulfur cluster proteins results in degradation and breakdown of the cluster to generate dinitrosyl iron complexes (DNICs). In some cases the formation of DNICs from such cluster systems can lead to activation of a regulatory pathway or the loss of enzyme activity. In order to understand the basic chemistry underlying these processes, we have investigated the reactions of NO with synthetic [2Fe-2S] and [ ...