Development of an oxazole conjunctive reagent and application to the total synthesis of siphonazoles

J Zhang, EA Polishchuk, J Chen…

Index: Zhang, Jianmin; Polishchuk, Elena A.; Chen, Jie; Ciufolini, Marco A. Journal of Organic Chemistry, 2009 , vol. 74, # 23 p. 9140 - 9151

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Citation Number: 28

Abstract

The preparation of 4-carbethoxy-5-methyl-2-(phenylsulfonyl) methyloxazole and its use in the elaboration of more complex oxazoles are described. A total synthesis of the unique natural products siphonazoles A and B, illustrates an application of this building block. A discussion of the biological activity of the siphonazoles is also presented.