Synthesis of chromone carboxamide derivatives with antioxidative and calpain inhibitory properties

SH Kim, YH Lee, SY Jung, HJ Kim, C Jin…

Index: Kim, Sang Hoon; Lee, Young Hoon; Jung, Seo Yun; Kim, Hyoung Ja; Jin, Changbae; Lee, Yong Sup European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1721 - 1728

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Citation Number: 14

Abstract

The overactivation of μ-calpain can cause serious cell damage in several diseases. Furthermore, cell death in a number of neurodegenerative disorders is linked to the overproduction of reactive oxygen species. Therefore, antioxidants and μ-calpain inhibitors could have the therapeutic potentials to treat cell death related diseases. New chromone carboxamide derivatives 3 were synthesized to provide alternative μ-calpain inhibitors to ...