The Reaction of Epichlorohydrin with Secondary Amines

DL Heywood, B Phillips

Index: Heywood; Phillips Journal of the American Chemical Society, 1958 , vol. 80, p. 1257

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Citation Number: 30

Abstract

Reaction of unsubstituted cyclic secondary amines and epichlorohydrin followed by treatment with alkali gare, when allowed to proceed to completion, 2, 5-bis- (dialkylaminomethy1)-$-dioxanes. The structures were proved by independent synthesis and conditions were determined for directing the reactions to either the dioxanes or the N-(2, 3-epox:~ propyl)-dialkylamines as the major products.