Total synthesis of 11-R, 12-R-dihydroxyeicosatrienoic acid, a metabolite of the cytochrome P-450 epoxygenase pathway

SS Wang, J Rokach

Index: Wang, Steven S.; Rokach, Joshua Tetrahedron Letters, 1994 , vol. 35, # 34 p. 6239 - 6242

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Citation Number: 4

Abstract

The first total and enantioselective synthesis of 11-R,12-R-dihydroxy-5,8,14-eicosatrienoic acid is reported. We have used the carbohydrate 2-deoxy-D-glucose as a masked 1,6-dialdehyde precursor to perform the synthesis. The availability of this material will allow, among other things, the testing of the hypothesis that it can be a biochemical precursor to 12-R-HETE in vivo. ... The first total and enantioselective synthesis of title compound has been ...