Potential Anticancer Agents. 1 XVIII. Synthesis of Substituted 4, 5-Trimethylenepyrimidines

LO Ross, L Goodman, BR Baker

Index: Ross et al. Journal of the American Chemical Society, 1959 , vol. 81, p. 3108,3111

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Citation Number: 25

Abstract

The condensations of 2-c~ rbethouycyclopentanone (111) with guanidine, thiourea and 2- methyl-2-thiopseudourea led to 2-amino-4-hydroxy-(IV), 4-hydrouy-2-mercapto-(XX) and 4- hydroxy-2-(methylthio)-5, G-trimethq. lenepyrimidine (XXIX), respectively. Compounds I\-, XX and XXIX mere converted to a variety of substituted 4, 5-trimethylenepyriniidines, several of which are closely related structurally to biologically important purines.