Thallium in organic synthesis. 62. A convenient synthesis of. alpha.-arylsuccinic acids

…, RA Conley, AH Katz, A McKillop

Index: Taylor, Edward C.; Conley, Richard A.; Katz, Alan H; McKillop, Alexander Journal of Organic Chemistry, 1984 , vol. 49, # 20 p. 3840 - 3841

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Citation Number: 8

Abstract

The" acetophenone rearrangement"(eq 1), 3-5 which is carried out by treatment of aralkyl ketones with thallium (II1) trinitrate (TTN) in a mixture of methanol and trimethyl orthoformate (TMOF), or with TTN absorbed upon K-10 montmorillonite clay, 6 provides a high-yield, mild, one-step procedure for the synthesis of arylacetic acids and a-alkylarylacetic acids (as their methyl esters) which are of considerable interest as antiinflammatory, analgesic, and ...

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