Tetrahedron

Oxidative ring opening of 3-hydroxyquinoline-2, 4 (1H, 3H)-diones into N-(α-ketoacyl) anthranilic acids

S Kafka, K Proisl, V Kašpárková, D Urankar, R Kimmel…

Index: Kafka, Stanislav; Proisl, Karel; Kasparkova, Vera; Urankar, Damijana; Kimmel, Roman; Kosmrlj, Janez Tetrahedron, 2013 , vol. 69, # 51 p. 10826 - 10835

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Citation Number: 9

Abstract

Abstract N-(α-Ketoacyl) anthranilic acids were prepared by oxidative ring opening of 3- hydroxyquinoline-2, 4 (1H, 3H)-diones by using paraperiodic acid (H 5 IO 6) or sodium periodate (NaIO 4). The optimisation of the reaction conditions is described as well as the utilisation of N-(α-ketoacyl) anthranilic acids in the preparation of anthranilic acid hydrochlorides.

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