Synthesis of α-trifluoromethyl-α-hydroxycarboxylate dervatives and their phosphorus-containing analogs with the use of fluorinated diazo compounds

…, DV Vorob'eva, SN Osipov, IP Beletskaya

Index: Titanyuk; Vorob'eva; Osipov; Beletskaya Russian Journal of Organic Chemistry, 2010 , vol. 46, # 5 p. 619 - 623

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Citation Number: 9

Abstract

Abstract Approach was developed underlain by the use of fluorinated diazocompounds to the synthesis of derivatives of α-trifluoromethyl-α-hydroxycarboxylic acids and their phosphorus-containing analogs, α-trifluoromethyl-α-hydroxyphosphonic acids. Methyl 2- diazo-3, 3, 3-trifluoropropionate and diethyl 1-diazo-2, 2, 2-trifluoroethylphosphonate under the action of catalytic quantities of dirhodium tetraacetate Rh 2 (OAc) 4 easily inserted into ...