Synthesis and carcinogenic activity of 5-fluoro-7-(oxygenated methyl)-12-methylbenz [a] anthracenes

…, MM Hashem, R Kannan, V Sankaran

Index: Newman; Fikes; Hashem; Kannan; Sankaran Journal of Medicinal Chemistry, 1978 , vol. 21, # 10 p. 1076 - 1078

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Citation Number: 6

Abstract

Compound 5 produced a variable effect on hepatic triglyceride content since low doses (10 mg/kg) reduced but higher doses (50 and 100 mg/kg) elevated liver triglyceride levels (Table V). The high doses (50 and 100 mg/kg) of compound 5 did not lower hepatic triglyceride biosynthesis measured in vivo more than a 10 mg/kg dose (Table IV). Therefore, the significantly lower serum triglyceride concentration associated with the 50 mg/kg dose of ...