Journal of medicinal chemistry

Antiparasitic 5-nitrothiazoles and 5-nitro-4-thiazolines. 2

PJ Islip, MD Closier, JE Weale

Index: Islip,P.J. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 1027 - 1030

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Citation Number: 8

Abstract

The synthesis of a wide variety of 3-[N-(5-nitro-2-thiazolyl) acylamino] propionamides IV and [l-(2-substituted ethyl)-1-(5-nitro-2-thiazolyl)-3-substituted] ureas V as potential antibacterial and antiparasitic agents is described. Treatment of 2-bromo-5-nitrothiazole with 3- aminopropionitrile afforded 3-[(S-nitro-2-thiazolyl) amino] propionitrile (l), the key intermediate. Some of the compounds prepared showed potent schistosomicidal, ...