Synthesis and antifungal activity of novel sulfoxide derivatives containing trimethoxyphenyl substituted 1, 3, 4-thiadiazole and 1, 3, 4-oxadiazole moiety

F Liu, XQ Luo, BA Song, PS Bhadury, S Yang…

Index: Liu, Fang; Luo, Xiao-Qiong; Song, Bao-An; Bhadury, Pinaki S.; Yang, Song; Jin, Lin-Hong; Xue, Wei; Hu, De-Yu Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 3632 - 3640

Full Text: HTML

Citation Number: 144

Abstract

Selective oxidation of sulfides 7 or 8 to sulfoxides 9 or 10 is achieved by mCPBA. The structures of the compounds 9 or 10 are confirmed by elemental analysis, IR, and 1H NMR. The bioassay results showed that title compound 10a possess high antifungal activities with EC50 values ranging from 19.91 to 63.97 μg/mL. The mechanism of action of 10a against Sclerotinia sclerotiorum was studied. After treating with compound 10a at 100μg/mL for ...