Selective Reductions of 1-(Carbonyl) Substituted 2-Nitro-Imidazoles with Alkali Metal Borohydrides and with Borane. Tetrahydrofuran

MD Threadgill, P Webb

Index: Threadgill, Michael D.; Webb, Paul Synthetic Communications, 1990 , vol. 20, # 15 p. 2319 - 2325

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Abstract

I-Substituted 2-nitroimidazoles sensitise14 hypoxic cells to killing by ionising radiation by acting as electron-affinic mimics of dioxygen and are reduced readily by biological systcmsS to substances which can be selectively rctained and be cytotoxic towards cells dcficicnt in dioxygen6. During our programme of synthesis of substituted 2-nitroimidazoles, selcctivc rcductions of various types of carbonyl group have been required while retaining he nitroheterocycle (El, = ca. -380 ...