Tetrahedron: Asymmetry

A synthesis of (S)-α-(fluorodiphenylmethyl) alkylamines by HF–pyridine treatment of 4-alkyl-5, 5-diphenyl-oxazolidinones

D O'Hagan, F Royer, M Tavasli

Index: O'Hagan, David; Royer, Frederique; Tavasli, Mustafa Tetrahedron Asymmetry, 2000 , vol. 11, # 9 p. 2033 - 2036

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Citation Number: 12

Abstract

Treatment of enantiomerically pure (S)-4-alkyl-5, 5-diphenyl-oxazolidinones, themselves derived from appropriate amino acids, with HF–pyridine (Olah's reagent) generated a range of (S)-α-(fluorodiphenylmethyl) alkylamines. These compounds represent a novel range of fluorinated chiral amines.

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