Pentamidine
Suppliers
Names
[ CAS No. ]:
100-33-4
[ Name ]:
Pentamidine
[Synonym ]:
4,4'-[Pentane-1,5-diylbis(oxy)]dibenzenecarboximidamide
4,4'-(Pentane-1,5-diylbis(oxy))dibenzimidamide
pentamidine
Benzenecarboximidamide, 4,4'-(1,5-pentanediylbis(oxy))bis-
EINECS 202-841-0
Benzenecarboximidamide, 4,4'-[1,5-pentanediylbis(oxy)]bis-
4,4'-[1,5-Pentanediylbis(oxy)]dibenzenecarboximidamide
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
539.4±60.0 °C at 760 mmHg
[ Melting Point ]:
186ºC (dec.)
[ Molecular Formula ]:
C19H24N4O2
[ Molecular Weight ]:
340.419
[ Flash Point ]:
280.0±32.9 °C
[ Exact Mass ]:
340.189911
[ PSA ]:
118.20000
[ LogP ]:
2.47
[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C
[ Index of Refraction ]:
1.593
[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CV6475000
- CHEMICAL NAME :
- Benzamidine, 4,4'-(pentamethylenedioxy)di-
- CAS REGISTRY NUMBER :
- 100-33-4
- BEILSTEIN REFERENCE NO. :
- 3159790
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C19-H24-N4-O2
- MOLECULAR WEIGHT :
- 340.47
- WISWESSER LINE NOTATION :
- MUYZR DO5OR DYZUM
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 28 mg/kg/1W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908- Volume(issue)/page/year: 145,2247,1985
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 4 mg/kg/3D
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature increase
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 246,338,1944
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Endocrine - hypoglycemia
- REFERENCE :
- AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 99,128,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 18,794,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BSCFAS Bulletin de la Societe Chimique de France. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1864- Volume(issue)/page/year: -,376,1968
Safety Information
[ Hazard Codes ]:
Xi
[ RIDADR ]:
UN 3249
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2925290090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2925290090
[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%