Phenylhydrazine

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Names

[ CAS No. ]:
100-63-0

[ Name ]:
Phenylhydrazine

[Synonym ]:
Fenilidrazina [Italian]
EINECS 202-873-5
Hydrazine,phenyl
Fenylhydrazine [Dutch]
Hydrazinobenzene
Hydrazine-benzene
Phenylhydrazine
MFCD00007573
Phenylhydrazin
N-phenyl hydrazine
Edaravone Impurity 3

Chemical & Physical Properties

[ Density]:
1.099 g/mL at 25 °C(lit.)

[ Boiling Point ]:
238-241 °C(lit.)

[ Melting Point ]:
19 °C

[ Molecular Formula ]:
C6H8N2

[ Molecular Weight ]:
108.14100

[ Flash Point ]:
89 ºC

[ Exact Mass ]:
108.06900

[ PSA ]:
38.05000

[ LogP ]:
1.74550

[ Vapour density ]:
4.3 (vs air)

[ Vapour Pressure ]:
<0.1 mm Hg ( 20 °C)

[ Index of Refraction ]:
n20/D 1.607(lit.)

[ Stability ]:
Stable, but may decompose in sunlight. May be air or light sensitive. Incompatible with strong oxidizing agents, metal oxides.

[ Water Solubility ]:
145 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MV8925000
CHEMICAL NAME :
Hydrazine, phenyl-
CAS REGISTRY NUMBER :
100-63-0
BEILSTEIN REFERENCE NO. :
0606080
LAST UPDATED :
199806
DATA ITEMS CITED :
48
MOLECULAR FORMULA :
C6-H8-N2
MOLECULAR WEIGHT :
108.16
WISWESSER LINE NOTATION :
ZMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
188 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2610 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
175 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2120 mg/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
170 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
120 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - muscle contraction or spasticity
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
70 mg/kg/7D-I
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count Blood - changes in platelet count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5200 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
30 mg/kg
SEX/DURATION :
female 17-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1469,1981 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.44 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 5 ppm (22 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,207,1971 OSHA PEL (Gen Indu):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 5 ppm (22 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 5 ppm (20 mg/m3);Skin JAN 1993 OEL-AUSTRALIA:TWA 5 ppm (20 mg/m3);STEL 10 ppm;Skin;Carcinogen JAN 1993 OEL-BELGIUM:TWA 5 ppm (22 mg/m3);STEL 10 ppm (44 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.6 mg/m3);Skin JAN 1993 OEL-FINLAND:STEL 5 ppm (22 mg/m3);Skin JAN 1993 OEL-GERMANY:TWA 5 ppm (22 mg/m3);Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 5 ppm (22 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (22 mg/m3) JAN 1993 OEL-TURKEY:TWA 5 ppm (22 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (20 mg/m3);STEL 10 ppm;Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO HYDRAZINES-air:CA CL 0.03 ppm/120M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENYLHYDRAZINE-air:CA CL 0.14 ppm/120M (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 57300 No. of Facilities: 56 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 1120 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 57300 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 212 (estimated) No. of Female Employees: 19 (estimated)

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H317-H319-H331-H341-H350-H372-H400

[ Precautionary Statements ]:
P201-P261-P273-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R23/24/25;R36/38;R43;R45;R48/23/24/25;R50;R68

[ Safety Phrases ]:
S53-S45-S61

[ RIDADR ]:
UN 2572 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
MV8925000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Bromobenzene
  • Iodobenzene
  • nitrobenzene
  • Chlorobenzene
  • Phenylhydrazine hydrochloride
  • Benzenediazonium tetrafluoroborate
  • Benzenediazonium chloride
  • Benzenesulfonic acid,4-methyl-, phenyl ester
  • benzenediazonium

DownStream

  • 2-(3,5-diamino-1-phenylpyrazol-4-yl)-1-phenylethanone
  • 5-ethyl-1-methyl-2-phenylpyrazol-3-one
  • 1-(benzylideneamino)indole-2,3-dione
  • 4-[(phenylhydrazinylidene)methyl]benzonitrile
  • 1,3-DIPHENYLPYRAZOLE-4-PROPIONIC ACID
  • 1H-Pyrazole,3-(4-chlorophenyl)-4,5-dihydro-1,5-diphenyl-
  • 2-ethyl-2-phenyl-3,4-dihydropyrazol-2-ium-5-amine,iodide
  • 1-(3-Methyl-1-phenyl-1H-pyrazol-4-yl)ethanone
  • 4-acetyl-5-methyl-1-phenylpyrazole
  • 3,5-Dimethyl-1-phenyl-1H-pyrazole-4-carbaldehyde

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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Related Compounds

  • phenylhydrazine
  • phenylhydrazine
  • Phenylhydrazine-d5
  • Boc-phenylhydrazine
  • 4-F-phenylhydrazine
  • 4-Br-phenylhydrazine