N-Phenylhydroxylamine

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Names

[ CAS No. ]:
100-65-2

[ Name ]:
N-Phenylhydroxylamine

[Synonym ]:
N-Phenylhydroxylamine
EINECS 202-875-6

Chemical & Physical Properties

[ Density]:
1.214g/cm3

[ Boiling Point ]:
215.8ºC at 760mmHg

[ Melting Point ]:
83 - 84ºC

[ Molecular Formula ]:
C6H7NO

[ Molecular Weight ]:
109.12600

[ Flash Point ]:
120.2ºC

[ Exact Mass ]:
109.05300

[ PSA ]:
32.26000

[ LogP ]:
1.56070

[ Vapour Pressure ]:
0.085mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
?20°C

[ Stability ]:
Unstable - deteriorates with storage. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NC4900000
CHEMICAL NAME :
Hydroxylamine, N-phenyl-
CAS REGISTRY NUMBER :
100-65-2
BEILSTEIN REFERENCE NO. :
0507174
LAST UPDATED :
199712
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C6-H7-N-O
MOLECULAR WEIGHT :
109.14
WISWESSER LINE NOTATION :
QMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
DOSE/DURATION :
500 ug/kg
TOXIC EFFECTS :
Skin and Appendages - primary irritation (after topical exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
247 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1060 mg/kg/13W-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
34 gm/kg/50D-I
TOXIC EFFECTS :
Blood - other changes Nutritional and Gross Metabolic - other changes

MUTATION DATA

TYPE OF TEST :
Gene conversion and mitotic recombination
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
2 umol/L
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 86,155,1995

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S45

[ RIDADR ]:
UN 2811

[ RTECS ]:
NC4900000

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • nitrobenzene
  • Nitrosobenzene
  • (Z)-(4-methoxyphenyl)methylidene-oxido-phenyl-azanium
  • Malononitrile
  • (Z)-N-((1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)methylene)aniline oxide
  • (4-methylphenyl)methylidene-oxido-phenyl-azanium
  • Ethyl cyanoacetate
  • N-acetoacetylphenylhydroxyloamine

DownStream

  • N-hydroxy-2,2-dimethyl-N-phenylpropanamide
  • 4-Methoxydiphenylamine
  • 2-methoxy-N-phenylaniline
  • 4'-Methoxy-4-biphenylamine
  • 4'-METHOXY-BIPHENYL-2-YLAMINE
  • [1,1'-biphenyl]-2-amine,N-phenyl
  • 1,1':2',1''-Terphenyl]-4-amine
  • 4'-(phenyl)biphenyl-2-amine
  • N-Phenyl-4-biphenylamine
  • 2-(2-aminophenyl)biphenyl

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

In situ infrared monitoring of the solid/liquid catalyst interface during the three-phase hydrogenation of nitrobenzene over nanosized Au on TiO2.

Phys. Chem. Chem. Phys. 13(27) , 12463-71, (2011)

The three-phase hydrogenation of nitrobenzene catalysed by nanosized gold over titania was investigated in a slurry. Simultaneous in situ ATR-FTIR monitoring of the liquid phase and at the solid/liqui...

Genotoxic activities of aniline and its metabolites and their relationship to the carcinogenicity of aniline in the spleen of rats.

Crit. Rev. Toxicol. 35(10) , 783-835, (2005)

Aniline (in the form of its hydrochloride) has been shown to induce a rather rare spectrum of tumors in the spleen of Fischer 344 rats. The dose levels necessary for this carcinogenic activity were in...

Biotransformation of hydroxylaminobenzene and aminophenol by Pseudomonas putida 2NP8 cells grown in the presence of 3-nitrophenol.

Appl. Environ. Microbiol. 66(6) , 2336-42, (2000)

Biotransformation products of hydroxylaminobenzene and aminophenol produced by 3-nitrophenol-grown cells of Pseudomonas putida 2NP8, a strain grown on 2- and 3-nitrophenol, were characterized. Ammonia...


More Articles

Related Compounds

  • p-Br-N-phenylhydroxylamine
  • N-Boc-N-phenylhydroxylamine
  • N-PHENYLHYDROXYLAMINE OXALATE
  • O-allyl-N-phenylhydroxylamine
  • 4-Nitro-N-phenylhydroxylamine
  • N-ethyl-N-phenylhydroxylamine
  • 1,3,4,12-Tetrahydro-12-methylindazolo[3,2-b]quinazolin-7(2H)-one
  • 3-(Quinolin-2-yl)phenanthro[9,10-e][1,2,4]triazine
  • N-(2-(furan-2-yl)-2-(1H-pyrazol-1-yl)ethyl)-3,3-dimethylbutanamide
  • 1-[4-(difluoromethyl)phenyl]-N-methylmethanesulfonamide
  • 1-(2,3-Difluorophenyl)-N-methylmethanesulfonamide
  • (2R)-2-ethynyl-2-methyl-1-pyrrolidineacetic acid 1,1-dimethylethyl ester
  • 1,3-Di(2-thienyl)-2-buten-1-one
  • Rel-(3Ar,5R,7Ar)-5-(3-Methyl-1,2,4-Oxadiazol-5-Yl)Octahydropyrano[3,2-B]Pyrrole
  • 2-((1H-Imidazol-1-Yl)Methyl)-7,8,9,10-Tetrahydropyrimido[1,2-A][1,4]Diazepin-4(6H)-One
  • N-[(3R,3aS,7aR)-1,2,3,3a,5,6,7,7a-octahydropyrano[3,2-b]pyrrol-3-yl]-1-methyl-pyrrole-2-carboxamide
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