Anisole

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Names

[ CAS No. ]:
100-66-3

[ Name ]:
Anisole

[Synonym ]:
Methoxybenzene
Ether, methyl phenyl
Phenol methyl ether
Phenyl methyl ether
Phenoxymethane
Anizol
EINECS 202-876-1
Anisole
Benzene, methoxy
4-methoxybenzene
Methyl phenyl ether
MFCD00008354
Benzene,methoxy
Anisole,AcroSeal,Extra Dry
Anisol
Benzene, methoxy-
methoxy benzene

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
153.6±0.0 °C at 760 mmHg

[ Melting Point ]:
-37 °C

[ Molecular Formula ]:
C₇H₈O

[ Molecular Weight ]:
108.138

[ Flash Point ]:
51.7±0.0 °C

[ Exact Mass ]:
108.057518

[ PSA ]:
9.23000

[ LogP ]:
2.13

[ Vapour density ]:
3.7 (vs air)

[ Vapour Pressure ]:
4.2±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.492

[ Stability ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
1.6 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8050000

CHEMICAL NAME :: Anisole

CAS REGISTRY NUMBER :: 100-66-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C7-H8-O

MOLECULAR WEIGHT :: 108.15

WISWESSER LINE NOTATION :: 1OR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5000 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3021 mg/m3/2H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 25 umol/L

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 54,133,1986 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1533 No. of Facilities: 4 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 469 (estimated)

Safety Information

[ Symbol ]:

GHS02

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226

[ Supplemental HS ]:
Repeated exposure may cause skin dryness or cracking.

[ Precautionary Statements ]:
P210-P370 + P378

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R10;R20;R38

[ Safety Phrases ]:
S37/39-S26-S16-S24/25

[ RIDADR ]:
UN 2222 3/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
BZ8050000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

Precursor & DownStream

Precursor

DownStream

(3-bromo-4-methoxyphenyl)-(4-methoxyphenyl)methanone
Neocryptotanshinone
trifluoromethyl 4-methoxybenzenecarbodithioate
3-(4-CHLOROPHENYL)-4'-METHOXYPROPIOPHENONE
4,4-bis(4-methoxyphenyl)but-3-enoic acid
4-(4-Methoxyphenyl)-4-oxobutanoic acid
1-fluoro-4-(3-methoxyphenyl)benzene
4-FLUORO-4'-METHOXYBIPHENYL
1-fluoro-4-(2-methoxyphenyl)benzene
4-Nitroanisole

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