3-Methylanisole

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Names

[ CAS No. ]:
100-84-5

[ Name ]:
3-Methylanisole

[Synonym ]:
3-Methoxytoluene
M-METHYLANISOLE
m-Cresol Methyl Ether
Benzene, 1-methoxy-3-methyl-
EINECS 202-893-4
3-Methoxtoluene
Methyl 3-methylphenyl ether
m-Methoxytoluene
3-methylmethoxybenzene
METHYL-M-CRESOL
3-Methylanisole
m-methyl-anisol
3-MEHYLANISOLE
MFCD00008395
1-Methoxy-3-methylbenzene
Anisole,m-methyl
meta-methylanisole
AMBROL
3-methyl-anisole

Chemical & Physical Properties

[ Density]:
0.969

[ Boiling Point ]:
175-176 ºC

[ Melting Point ]:
-47ºC

[ Molecular Formula ]:
C₈H₁₀O

[ Molecular Weight ]:
122.164

[ Flash Point ]:
54 ºC

[ Exact Mass ]:
122.073166

[ PSA ]:
9.23000

[ LogP ]:
2.59

[ Vapour Pressure ]:
1.8±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.512-1.514

[ Storage condition ]:
Flammables area

[ Stability ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ8778000

CHEMICAL NAME :: Anisole, m-methyl-

CAS REGISTRY NUMBER :: 100-84-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H10-O

MOLECULAR WEIGHT :: 122.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,214,1954

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H302

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R10;R22

[ Safety Phrases ]:
S16-S23-S24/25

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BZ8778000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2909309090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-Methoxybenzyl alcohol
3-Methoxybenzonitrile
2-methoxy-6-methylphenyl trifluoromethanesulfonate
m-Cresol
Dimethyl sulfate
4-Bromo-3-methyl-anisole
1-iodo-4-methoxy-2-methyl-benzene
2-(tert-butylsulfonyl)-1-methoxy-3-methylbenzene
m-Anisaldehyde
2-tert-butylsulfinyl-3-methoxytoluene

DownStream

1,2,3-trimethoxy-5-[2-(3-methoxyphenyl)ethyl]benzene
1-(5-chloro-4-methoxy-2-methylphenyl)ethanone
(3-methylphenyl) methanesulfonate
4-(3-Methoxyphenyl)-1-butanol
2-Hydroxy-3-methylbenzaldehyde
2-Methoxy-6-methylaniline
2,5-Dimethylphenol
2,3-Dimethylphenol
2,3,4,5,6-Pentamethylphenol
m-Cresol

Customs

[ HS Code ]: 2909309090

[ Summary ]:
2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Expedient Route to the functionalized calyciphylline A-type skeleton via a Michael addition-RCM strategy.

Org. Lett. 13(19) , 5132-5, (2011)

An efficient, robust, and scalable strategy to access the functionalized core of calyciphylline A-type alkaloids has been developed starting from commercially available 3-methylanisole. Key features o...