Hymexazol

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Names

[ Name ]:
Hymexazol

[Synonym ]:
Hydroxyisoxazole
5-methyl-3-isoxazolol
Tachigaren
3(2H)-isoxazolone, 5-methyl-, compd. with 5-methyl-3-isoxazolol (1:1)
Bucide
Itachigarden
Hymexazole
5-Methylisoxazol-3(2H)-one
5-methylisoxazol-3-ol
3-Hydroxy-5-Methylisoxazole
MFCD00144468
5-methyl-1,2-oxazol-3-ol
5-methyl-3(2H)-isoxazolone
Hymexazol
5-methyl-3-hydroxyisoxazole
5-methyl-1,2-oxazol-3-one
EINECS 233-000-6

Chemical & Physical Properties

[ Density]:
1.185 g/cm3

[ Boiling Point ]:
228.2ºC at 760 mmHg

[ Melting Point ]:
80°C

[ Molecular Formula ]:
C₄H₅NO₂

[ Molecular Weight ]:
198.176

[ Flash Point ]:
91.8ºC

[ Exact Mass ]:
198.064056

[ PSA ]:
46.00000

[ LogP ]:
0.27630

[ Vapour Pressure ]:
0.0493mmHg at 25°C

[ Index of Refraction ]:
1.467

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NY2932000

CHEMICAL NAME :: Isoxazole, 3-hydroxy-5-methyl-

CAS REGISTRY NUMBER :: 10004-44-1

LAST UPDATED :: 199312

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C4-H5-N-O2

MOLECULAR WEIGHT :: 99.10

WISWESSER LINE NOTATION :: T5NOJ C1 EQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3112 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1884 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1968 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1167 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 445 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >2 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 3 mg/L

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 8,173,1983

Safety Information

[ Hazard Codes ]:
Xi;Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26-S39-S61

[ WGK Germany ]:
3

[ RTECS ]:
NY2932000

[ HS Code ]:
2934999024

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Ethyl acetoacetate
N-(trimethylsilyloxy)-N-(trimethylsilyl)acetoacetamide
Ethyl tetrolate
Diketene
3-Oxothiobutyric acid S-ethyl ester
Methyl acetoacetate

DownStream

3-Methoxy-5-Methyl-isoxazole
2,5-dimethyl-4-isothiazolin-3-one
3-ETHOXY-5-METHYLISOXAZOLE
2-(chloromethyl)-5-methyl-1,2-oxazol-3-one
2-benzyl-5-methyl-1,2-oxazol-3-one
3-benzyloxy-5-methylisoxazole
(3-Oxo-2,3-dihydro-1,2-oxazol-5-yl)acetic acid

Customs

[ HS Code ]: 2934999024

[ Summary ]:
HS:2934999024 5-methylisoxazol-3(2h)-one VAT:17.0% Tax rebate rate:9.0% Supervision conditions:S MFN tariff:6.5% General tariff:20.0%

Related Compounds

hymexazol
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
2-(Aminomethyl)-3-cyano-4-(difluoromethyl)-6-(trifluoromethoxy)pyridine
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-[(4,4-Dimethylcyclohexyl)oxy]piperidine