3α-Hydroxy Tibolone

Names

[ CAS No. ]:
100239-44-9

[ Name ]:
3α-Hydroxy Tibolone

[Synonym ]:
(3R,7R,8R,9S,13S,14S,17R)-17-ethynyl-7,13-dimethyl-2,3,4,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
Estr-5(10)-ene-3,17-diol, 17-ethynyl-7-methyl-, (3α,7α,17β)-
(3α,7α,17α)-7-Methyl-19-norpregn-5(10)-en-20-yne-3,17-diol

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
449.1±45.0 °C at 760 mmHg

[ Melting Point ]:
72-74ºC

[ Molecular Formula ]:
C21H30O2

[ Molecular Weight ]:
314.462

[ Flash Point ]:
201.3±23.3 °C

[ Exact Mass ]:
314.224579

[ PSA ]:
40.46000

[ LogP ]:
4.45

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.578

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Tibolone(Liviella)(Livial)
  • 17α-ethynyl-7α-methyl-5(10)-estren-3ξ,17β-diol

DownStream

  • 3β-Hydroxy Tibolone

Related Compounds

  • 3α-Hydroxy Tibolone 17-O-Sulfate
  • 3α-hydroxy-7-oxo-2β-benzyloxymethylbicyclo[3.3.0]octane tetrahydropyranyl ether (α-isomer)
  • 3α-hydroxy-6-oxo-5α-cholanoic acid-(24)-methyl ester
  • 3α-Hydroxy-4β-hydroxymethyl-4,8-dimethyl-18-nor-16-oxa-5α-androsta-13(17),14-dien-2-one
  • 3α-Hydroxy-4α,5α,7α,11β-H-eudesman-12,8β-olid
  • 3α-hydroxy-3-deoxogedunin