phosphoryl trichloride

MOLECULAR FORMULA :

Cl3-O-P

MOLECULAR WEIGHT :

153.32

WISWESSER LINE NOTATION :

P O G3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

36 mg/kg

TOXIC EFFECTS :

Gastrointestinal - other changes Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534840

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

32 ppm/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,17,1972

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534840

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

53 ppm/4H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - irritability Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,470,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

1340 ug/m3/17W-I

REFERENCE :

JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957- Volume(issue)/page/year: 21,387,1977 *** REVIEWS *** ACGIH TLV-TWA 0.63 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.6 mg/m3);STEL 0.5 ppm (3 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.63 mg/m3);STEL 0.5 ppm (3.1 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.6 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.6 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.2 ppm (1 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.6 mg/m3) JAN 1993 OEL-RUSSIA:STEL 0.05 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.6 mg/m3);STEL 0.2 ppm (1.2 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.5 ppm (3 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (1.2 mg/m3);STEL 0.6 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHOSPHORUS OXYCHLORIDE-air:10H TWA 0.1 ppm;STEL 0.5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81931 No. of Facilities: 155 (estimated) No. of Industries: 7 No. of Occupations: 22 No. of Employees: 7258 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81931 No. of Facilities: 165 (estimated) No. of Industries: 9 No. of Occupations: 29 No. of Employees: 12587 (estimated) No. of Female Employees: 2945 (estimated)