Potassium tetrachloroplatinate(II)
Suppliers
Names
[ CAS No. ]:
10025-99-7
[ Name ]:
Potassium tetrachloroplatinate(II)
[Synonym ]:
EINECS 233-050-9
dipotassium,tetrachloroplatinum(2-)
Dipotassium tetrachloroplatinate(2-)
Potassium platinochloride
Platinate(2-), tetrachloro-, potassium (1:2)
Potassium tetrachloroplatinate
Platinous potassium chloride
Potasium tetrachloroplatinate (I)
Potassium tetrachloroplatinate(II)
Potassium chloroplatinite
MFCD00011378
Chemical & Physical Properties
[ Density]:
3.38 g/mL at 25 °C(lit.)
[ Melting Point ]:
250°C
[ Molecular Formula ]:
Cl4K2Pt
[ Molecular Weight ]:
415.08700
[ Exact Mass ]:
412.76800
[ LogP ]:
2.75550
[ Stability ]:
Stable. Incompatible with acids, strong oxidizing agents.
[ Water Solubility ]:
10 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TP1850000
- CHEMICAL NAME :
- Platinate(2-), tetrachloro-, dipotassium
- CAS REGISTRY NUMBER :
- 10025-99-7
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 34
- MOLECULAR FORMULA :
- Cl4-Pt.2K
- MOLECULAR WEIGHT :
- 415.09
- WISWESSER LINE NOTATION :
- KA2 PT-G4
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 8571 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - gastritis Kidney, Ureter, Bladder - renal function tests depressed Blood - eosinophilia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intradermal
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Skin and Appendages - primary irritation (after topical exposure) Skin and Appendages - corrosive (after topical exposure)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 65 umol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,1463,1980 *** REVIEWS *** ACGIH TLV-TWA 0.002 mg(Pt)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.002 mg(Pt)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,213,1971 OSHA PEL (Gen Indu):8H TWA 0.002 mg(Pt)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.002 mg(Pt)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.002 mg(Pt)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.002 mg(Pt)/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.002 mg(Pt)/m3 (dust) JAN 1993 OEL-AUSTRALIA:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-BELGIUM:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-DENMARK:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-FINLAND:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-GERMANY:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-HUNGARY:STEL 0.002 mg(Pt)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.002 mg(Pt)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
Safety Information
[ Symbol ]:
GHS05, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H315-H317-H318-H334
[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P342 + P311
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
[ Hazard Codes ]:
T:Toxic;
[ Risk Phrases ]:
R25;R38;R41;R42/43
[ Safety Phrases ]:
S22-S26-S36/37/39-S45
[ RIDADR ]:
UN 3288 6.1/PG 3
[ WGK Germany ]:
1
[ RTECS ]:
TP1850000
[ Packaging Group ]:
I; II; III
[ Hazard Class ]:
6.1
[ HS Code ]:
2922509090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Eur. J. Med. Chem. 89 , 77-87, (2014)
A new platinum(II) complex of [Pt(II)(L) (pn)]Cl·2H2O (1) (pn = 1,3-propanediamine) with 2-(4-methoxy-phenyl)imidazo [4,5-f]-[1,10]phenanthrolin (H-L) was synthesized and characterized. In complex 1, ...
Anticancer Res. 35 , 2783-94, (2015)
With the idea that platinum compounds that bind with DNA differently than cisplatin may be better-able to overcome platinum resistance in ovarian tumor, the monofunctional platinum complex tris(imidaz...
Gen. Physiol. Biophys. 17(1) , 25-36, (1998)
The interaction of platinum complexes with bovine heart pyruvate kinase (PK) was studied by absorption, CD, fluorescence spectroscopy and enzymic activity test. Our results showed that activity of PK ...