Cyclopentylamine

Names

[ CAS No. ]:
1003-03-8

[ Name ]:
Cyclopentylamine

[Synonym ]:
MFCD00001380
EINECS 213-697-3
Aminocyclopentane
UNII-4259VRY3GN
cyclopentanamine

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
110.0±8.0 °C at 760 mmHg

[ Melting Point ]:
-85°C

[ Molecular Formula ]:
C₅H₁₁N

[ Molecular Weight ]:
85.147

[ Flash Point ]:
17.2±0.0 °C

[ Exact Mass ]:
85.089149

[ PSA ]:
26.02000

[ LogP ]:
0.83

[ Vapour Pressure ]:
24.2±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.465

[ Storage condition ]:
Flammables area

[ Water Solubility ]:
MISCIBLE

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GY8452000

CHEMICAL NAME :: Cyclopentylamine

CAS REGISTRY NUMBER :: 1003-03-8

BEILSTEIN REFERENCE NO. :: 0635706

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C5-H11-N

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 5,108,1960

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H300-H315-H317-H318-H332

[ Precautionary Statements ]:
P210-P264-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable;T:Toxic;

[ Risk Phrases ]:
R11;R20;R25;R34;R43

[ Safety Phrases ]:
S16-S45-S36/37/39-S25-S26

[ RIDADR ]:
UN 2733 3/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
GY8452000

[ Packaging Group ]:
II

[ Hazard Class ]:
3

[ HS Code ]:
29213099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

nitrocyclopentane
2,4-DIFLUORO-N-(2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-3-YL)BENZENESULFONAMIDE
azidocyclopentane
cyclopentanone oxime
Cyclopentanone
cyclopentanone O-ethanoyloxime

DownStream

N-cyclopentyl-9-methylpurin-6-amine
Ro3280
3-(Cyclopentylamino)propionitrile
Cyclopentyl isothiocyanate
4'-nitrobenzanilide
N-cyclopentyl-4-(pyrrolidin-1-yl)picolinamide
N-picolinoylcyclopentylamine
ccpa
1-[(4-Methylphenyl)sulfonyl]pyrrolidine
4-Nitroaniline

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists.

J. Med. Chem. 56(19) , 7706-14, (2013)

Preclinical models of inflammatory diseases (e.g., neuropathic pain, rheumatoid arthritis, and multiple sclerosis) have pointed to a critical role of the chemokine receptor 2 (CCR2) and chemokine liga...

Cytostatic and antitumour properties of a new series of Pt (II) complexes with cyclopentylamine.

In Vivo 1(4) , 229-34, (1987)

Ten new Pt (II) complexes were synthesized and tested as potential antitumor drugs in vitro on KB human tumour cell line, and in vivo against four experimental tumour systems (P388, L1210, ADJ/PC6A an...

Influenza virus M2 protein: a molecular modelling study of the ion channel.

Protein Eng. 6(1) , 65-74, (1993)

The influenza A M2 protein forms cation-selective ion channels which are blocked by the anti-influenza drug amantadine. A molecular model of the M2 channel is presented in which a bundle of four paral...

methylcyclopentylamine
Phenylcyclopentylamine
N-Boc-Cyclopentylamine
benzylcyclopentylamine
2-allylcyclopentylamine
n-allylcyclopentylamine
N-{4-[(azepan-1-yl)methyl]-1,3-thiazol-2-yl}-3-(2-phenylethenesulfonamido)propanamide
n-((2-Methoxypyridin-3-yl)methyl)thiophene-2-carboxamide
N-(2-((2-methoxy-5-methylphenyl)amino)-2-oxoethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
(4-benzylpiperidino)(1,3,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-4-yl)methanone
1-(Prop-2-yn-1-yl)-4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazine
(2S)-2-amino-2-(4-phenylphenyl)acetonitrile
(R)-2-((2-(Trifluoromethyl)phenoxy)methyl)oxirane
(S)-2-(oxiran-2-ylmethyl)-1,2,3,4-tetrahydroisoquinoline
(2E)-3-[4-(Propan-2-yl)phenyl]-1-(thiophen-2-yl)prop-2-en-1-one
2-Chloro-3-methylquinoline-6-sulfonamide

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