Ro 22-3581

Names

[ Name ]:
Ro 22-3581

[Synonym ]:
4’-(1-Imidazolyl)acetophenone
1-(4-(1H-Imidazol-1-yl)phenyl)ethanone
MFCD00005282
1-(4-imidazol-1-ylphenyl)ethanone
4‘-(Imidazol-1-yl)acetophenone
EINECS 233-123-5

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
360.9ºC at 760 mmHg

[ Melting Point ]:
108-110 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₀N₂O

[ Molecular Weight ]:
186.21000

[ Flash Point ]:
172.1ºC

[ Exact Mass ]:
186.07900

[ PSA ]:
34.89000

[ LogP ]:
2.07490

[ Vapour Pressure ]:
2.15E-05mmHg at 25°C

[ Index of Refraction ]:
1.593

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Imidazole
1-(4-Iodophenyl)ethanone
1-(4-Bromophenyl)ethanone
4'-Fluoroacetophenone
1-(4-Chlorophenyl)ethanone
4-Acetylphenylboronic acid

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Suppression of urinary albumin excretion in diabetic rats by 4'(imidazol-1-yl) acetophenone, a selective inhibitor of thromboxane synthesis.

J. Lab. Clin. Med. 116(4) , 469-78, (1990)

Thromboxane contributes to the regulation of glomerular hemodynamics in experimental models of diabetes and has been implicated as mediator in some models of glomerular injury. In the present study we...

Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: effect of an imidazole derivative.

Prostaglandins 23(3) , 273-85, (1982)

We assessed the effect of a specific thromboxane synthetase inhibitor (an imidazole derivative) on pulmonary hemodynamics and the concentrations of TxB2 (TxA2), 6-keto-PGF1 alpha (PGI2), and PGF2 in p...

Attenuation of the development of hypertension in spontaneously hypertensive rats by the thromboxane synthetase inhibitor, 4'-(imidazol-1-yl) acetophenone.

Prostaglandins 24(2) , 237-44, (1982)

The compound 4'-(imidazol-1-yl) acetophenone was demonstrated to be a selective thromboxane (Tx) synthetase inhibitor in spontaneously hypertensive rats (SHR). Serum TxB2 concentrations (from clotted ...

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