Tosufloxacin pharmaceutical intermediate

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Names

[ Name ]:
Tosufloxacin pharmaceutical intermediate

[Synonym ]:
7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
7-chloro-1-(o,p-difluorophenyl)1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid
7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
Tosufloxacin pharmaceutical intermediate
7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro 4-oxo-1,8-naphthyridine-3-carboxylic acid
1,8-Naphthyridine-3-carboxylicacid,7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo
1,8-Naphthyridine-3-carboxylic acid, 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-
1-(2,4-difluoroanlino)-6-fluoro-7-chloro-1,4-dihydro-4-oxo-18-naphthylidine-3-carboxylic acid
7-chloro-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid
T66 BV EN GNJ CVQ ER BF DF& HG IF
1-(2,4-difluorophenyl)-6-fluoro-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
518.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₆ClF₃N₂O₃

[ Molecular Weight ]:
354.668

[ Flash Point ]:
267.2±30.1 °C

[ Exact Mass ]:
354.001892

[ PSA ]:
72.19000

[ LogP ]:
2.41

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.638

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE
Ethyl 2,6-dichloro-5-fluoro-pyridine-3-acetoacetate
Ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat
ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate
2,6-Dichloro-5-fluoronicotinic acid
2,6-dichloro-5-fluoronicotinoyl chloride