nicotinamide chloromethylate

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Names

[ CAS No. ]:
1005-24-9

[ Name ]:
nicotinamide chloromethylate

[Synonym ]:
N-methyl-3-carboxamidepyridinium chloride
nicotinamidemethochloride
n-methylnicotinic acid amide chloride
1-METHYLNICOTINAMIDE CHLORIDE
nicotinamide chloromethylate
MFCD00060042
Pyridinium, 3-(aminocarbonyl)-1-methyl-, chloride (1:1)
3-(Aminocarbonyl)-1-methylpyridinium Chloride
n-methylnicotinamidechloride
nicotinamidemethylchloride
1-METHYLNICOTINAMIDE CHLORIDE SALT
N1-Methylnicotinamide Chloride
EINECS 463-670-7
N-methyl-3-carbamoylpyridinium chloride
1-methyl-3-carbamoylpyridinium chloride
3-Carbamyl-1-methylpyridinium Chloride
3-Carbamoyl-1-methylpyridinium chloride
TRIGONELLAMIDE CHLORIDE
nipecotamidemethochloride

Chemical & Physical Properties

[ Melting Point ]:
207-209℃ (water acetone )

[ Molecular Formula ]:
C7H9ClN2O

[ Molecular Weight ]:
172.612

[ Exact Mass ]:
172.040344

[ PSA ]:
46.97000

[ Appearance of Characters ]:
crystalline | white

[ Storage condition ]:
room temp

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU1925000
CHEMICAL NAME :
Pyridinium, 3-(aminocarbonyl)-1-methyl-, chloride
CAS REGISTRY NUMBER :
1005-24-9
LAST UPDATED :
199012
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H9-N2-O.Cl
MOLECULAR WEIGHT :
172.63
WISWESSER LINE NOTATION :
T6KJ A1 CVZ &Q &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 62,19,1946

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UU1925000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Pyridinium,3-(aminocarbonyl)-1-methyl-, iodide (1:1)
  • Nicotinamide
  • 3-Pyridinecarboxamide,4-cyano-1,4-dihydro-1-methyl-(9CI)

DownStream

  • 3-Pyridinecarboxamide,4-cyano-1,4-dihydro-1-methyl-(9CI)
  • Trigonelline chloride
  • 1-Methyl-1,4-dihydronicotinamide
  • 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide
  • 3-Pyridinecarboxamide,1,6-dihydro-6-imino-1-methyl-(9CI)
  • 3,7-dimethyl-2,7-naphthyridin-1-one

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

¹H nuclear magnetic resonance based metabolic urinary profiling of patients with ischemic heart failure.

Clin. Biochem. 44(4) , 293-9, (2011)

We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics.Patients with systolic HF of ...

Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.

Br. J. Nutr. 110(12) , 2156-64, (2013)

Ecological evidence suggests that niacin (nicotinamide and nicotinic acid) fortification may be involved in the increased prevalence of obesity and type 2 diabetes, both of which are associated with i...

Single bout of endurance exercise increases NNMT activity in the liver and MNA concentration in plasma; the role of IL-6.

Pharmacol. Rep. 64(2) , 369-76, (2012)

Methylnicotinamide (MNA) displays vasoprotective activity, however, the regulation of the activity of nicotinamide-N-methyltransferase (NNMT), is largely unknown. We analyze a possible involvement of ...


More Articles

Related Compounds

  • nicotinamide β-D-arabinofuranoside
  • nicotinamide arabinoside adenine dinucleotide
  • nicotinamide guanine dinucleotide sodium salt
  • Nicotinamide,N-(6-amino-1,2,3,4-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinyl)- (7CI,8CI)
  • nicotinamide hydrobromide
  • Nicotinamide adenine dinucleotide phosphate
  • N-(6-((3-fluorobenzyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((4-fluorobenzyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-oxo-2-((4-(trifluoromethyl)phenyl)amino)ethyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-((2,5-dimethoxyphenyl)amino)-2-oxoethyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-((2-ethoxyphenyl)amino)-2-oxoethyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)amino)-2-oxoethyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-((2-fluorophenyl)amino)-2-oxoethyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-((4-fluorophenyl)amino)-2-oxoethyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-(benzylamino)-2-oxoethyl)thio)pyridazin-3-yl)propionamide
  • N-(6-((2-((benzo[d][1,3]dioxol-5-ylmethyl)amino)-2-oxoethyl)thio)pyridazin-3-yl)propionamide
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