Thiamet G

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Names

[ Name ]:
Thiamet G

[Synonym ]:
Thiamet G
Thiamet G0nDiscontinued
(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
5H-Pyrano[3,2-d]thiazole-6,7-diol, 2-(ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-, (3aR,5R,6S,7R,7aR)-

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
483.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₆N₂O₄S

[ Molecular Weight ]:
248.299

[ Flash Point ]:
246.0±31.5 °C

[ Exact Mass ]:
248.083084

[ PSA ]:
119.61000

[ LogP ]:
-0.09

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.729

[ Storage condition ]:
-20℃

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ RIDADR ]:
NONH for all modes of transport

Articles

Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.

Molecular Neurodegeneration 9 , 42, (2014)

Amyloid plaques and neurofibrillary tangles (NFTs) are the defining pathological hallmarks of Alzheimer's disease (AD). Increasing the quantity of the O-linked N-acetylglucosamine (O-GlcNAc) post-tran...

Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.

Nat. Chem. Biol. 8(4) , 393-9, (2012)

Oligomerization of tau is a key process contributing to the progressive death of neurons in Alzheimer's disease. Tau is modified by O-linked N-acetylglucosamine (O-GlcNAc), and O-GlcNAc can influence ...

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo.

.PubMed ID

Pathological hyperphosphorylation of the microtubule-associated protein tau is characteristic of Alzheimer's disease (AD) and the associated tauopathies. The reciprocal relationship between phosphoryl...

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3-Chloro-2-(3-methylphenyl)phenol
(4Z)-N-propylcyclooct-4-en-1-amine
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rac-(3R,4S)-4-cyclobutylpyrrolidin-3-ol
4-Methyl-2-azaspiro[4.6]undecan-6-ol
2-[(thiolan-2-yl)methyl]-2H-1,2,3-triazol-4-amine
4-Methyl-3-(prop-2-en-1-yloxy)cyclohexan-1-one

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