Hyoscyamine

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Names

[ CAS No. ]:
101-31-5

[ Name ]:
Hyoscyamine

[Synonym ]:
CYSTOSPAZ
L-Hyoscyamine
3a-Tropanyl S-(-)-Tropate
(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl-(2S)-3-hydroxy-2-phenylpropanoat
scopolamine HCl
SCOPINE TROPATE
Levsin
(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate
(S)-(-)-hyoscyamine
Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (αS)-
SCOPINE TROPATE HYDROCHLORIDE
Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (αS)-
MFCD00067306
(S)-atropine
Hyoscyamine
(-)-Hycosamine
(-)-Hyoscyamine
EINECS 202-933-0
Daturine
chlorhydratedescopolamine
Egacene
1-Tropic Acid Ester with Tropine
(-)-atropine
er),hcl
[3(S)-endo]-a-(Hydroxymethyl)benzeneacetic Acid 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester
Peptard
ScopolamineSeries
L-Tropine tropate
(2S)-(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
1aH,5aH-Tropan-3a-ol(-)-tropate (Ester)

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
429.8±45.0 °C at 760 mmHg

[ Melting Point ]:
108.5ºC

[ Molecular Formula ]:
C₁₇H₂₃NO₃

[ Molecular Weight ]:
289.369

[ Flash Point ]:
213.7±28.7 °C

[ Exact Mass ]:
289.167786

[ PSA ]:
49.77000

[ LogP ]:
1.53

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.581

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NH0875000

CHEMICAL NAME :: Hyoscyamine, (-)-

CAS REGISTRY NUMBER :: 101-31-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C17-H23-N-O3

MOLECULAR WEIGHT :: 289.41

WISWESSER LINE NOTATION :: T56 A ANTJ A1 GOVYR&1Q -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1471 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 24,138,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1029 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

Safety Information

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/28

[ Safety Phrases ]:
24-45

[ RIDADR ]:
UN 1544 6

[ WGK Germany ]:
3

[ RTECS ]:
NH0875000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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