Dicyclohexylamine

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Names

[ CAS No. ]:
101-83-7

[ Name ]:
Dicyclohexylamine

[Synonym ]:
biscyclohexylamine
EINECS 202-980-7
Dicyklohexylamin
N-Cyclohexyl-cyclohexylamine
Dicyclohexylamine
Bis(Cyclohexyl)Amine
DCHA
N-Cyclohexylcyclohexanamine
Dicyclohexylamine (DCHA)
MFCD00011658
Dodecahydrodiphenylamine
Cyclohexanamine,N-cyclohexyl
Dicha
N,N-DICYCLOHEXYLAMINE
Cyclohexanamine, N-cyclohexyl-

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
256.1±8.0 °C at 760 mmHg

[ Melting Point ]:
-2 °C

[ Molecular Formula ]:
C₁₂H₂₃N

[ Molecular Weight ]:
181.318

[ Flash Point ]:
96.1±0.0 °C

[ Exact Mass ]:
181.183044

[ PSA ]:
12.03000

[ LogP ]:
3.69

[ Vapour density ]:
6 (vs air)

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.488

[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents.

[ Water Solubility ]:
1 g/L (20 ºC)

[ Freezing Point ]:
-2℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HY4025000

CHEMICAL NAME :: Dicyclohexylamine

CAS REGISTRY NUMBER :: 101-83-7

BEILSTEIN REFERENCE NO. :: 0605923

LAST UPDATED :: 199710

DATA ITEMS CITED :: 18

MOLECULAR FORMULA :: C12-H23-N

MOLECULAR WEIGHT :: 181.36

WISWESSER LINE NOTATION :: L6TJ AM- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 373 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 135 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 gm/kg/52W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2404 mg/kg/48W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Human Leukocyte

DOSE/DURATION :: 200 ug/L

REFERENCE :: INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963- Volume(issue)/page/year: 9,188,1971 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,178,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1151 No. of Facilities: 60 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 368 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1151 No. of Facilities: 40 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 3412 (estimated) No. of Female Employees: 169 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311-H314-H410

[ Precautionary Statements ]:
P273-P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R22;R34;R50/53

[ Safety Phrases ]:
S26-S36/37/39-S45-S60-S61

[ RIDADR ]:
UN 2565 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
HY4025000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2921300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Cyclohexanol
N-Cyclohexylcyclohexylideneamine
N,N-dicyclohexyl-4-methylbenzenesulfonamide
Cyclohexanone
Cyclohexylamine
nitrobenzene
Diphenylamine
N,N-dicyclohexylmethanesulfonamide

DownStream

5-[(4-nitrophenyl)methoxy]-4,5-dioxopentanoate
3-Thiophenecarbonyl chloride
Z-Leu-OH.DCHA
Boc-His(Boc)-OH DCHA
2-Furoyl chloride
lithium,dicyclohexylazanide
Diphenylmethane
Benzene,1-methyl-4-[(4-methylphenyl)methyl]-
4,4'-di-tert-butyldiphenylmethane
N,N-DICYCLOHEXYL-2 BENZOTHIAZOLE SULFENAMIDE

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Evaluation of quadrupole-time-of-flight mass spectrometry in comprehensive two-dimensional gas chromatography.

J. Chromatogr. A. 1362 , 262-9, (2014)

Quadrupole time-of-flight mass spectrometry (Q-TOFMS) has been evaluated with respect to its applicability in comprehensive two-dimensional gas chromatography (GC×GC). At a maximum acquisition frequen...

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Application of two new series of ionic liquid matrices (ILMs) based on the two most predominantly used conventional organic matrices (Sinapinic acid and 2,5-DHB) in conjugation with various bases (ani...

Retention time prediction of compounds in Grob standard mixture for apolar capillary columns in temperature-programmed gas chromatography.

Anal. Bioanal. Chem 393(1) , 327-34, (2009)

This paper presents an extension of a previous investigation in which the behavior of nonpolar compounds in temperature-programmed gas chromatographic runs was predicted using thermodynamic (entropy a...