Dicyclohexylamine

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Names

[ CAS No. ]:
101-83-7

[ Name ]:
Dicyclohexylamine

[Synonym ]:
biscyclohexylamine
EINECS 202-980-7
Dicyklohexylamin
N-Cyclohexyl-cyclohexylamine
Dicyclohexylamine
Bis(Cyclohexyl)Amine
DCHA
N-Cyclohexylcyclohexanamine
Dicyclohexylamine (DCHA)
MFCD00011658
Dodecahydrodiphenylamine
Cyclohexanamine,N-cyclohexyl
Dicha
N,N-DICYCLOHEXYLAMINE
Cyclohexanamine, N-cyclohexyl-

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
256.1±8.0 °C at 760 mmHg

[ Melting Point ]:
-2 °C

[ Molecular Formula ]:
C12H23N

[ Molecular Weight ]:
181.318

[ Flash Point ]:
96.1±0.0 °C

[ Exact Mass ]:
181.183044

[ PSA ]:
12.03000

[ LogP ]:
3.69

[ Vapour density ]:
6 (vs air)

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.488

[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents.

[ Water Solubility ]:
1 g/L (20 ºC)

[ Freezing Point ]:
-2℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HY4025000
CHEMICAL NAME :
Dicyclohexylamine
CAS REGISTRY NUMBER :
101-83-7
BEILSTEIN REFERENCE NO. :
0605923
LAST UPDATED :
199710
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C12-H23-N
MOLECULAR WEIGHT :
181.36
WISWESSER LINE NOTATION :
L6TJ AM- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
373 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
40 gm/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2404 mg/kg/48W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human Leukocyte
DOSE/DURATION :
200 ug/L
REFERENCE :
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963- Volume(issue)/page/year: 9,188,1971 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,55,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,178,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 1 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1151 No. of Facilities: 60 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 368 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1151 No. of Facilities: 40 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 3412 (estimated) No. of Female Employees: 169 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301 + H311-H314-H410

[ Precautionary Statements ]:
P273-P280-P301 + P310 + P330-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R22;R34;R50/53

[ Safety Phrases ]:
S26-S36/37/39-S45-S60-S61

[ RIDADR ]:
UN 2565 8/PG 3

[ WGK Germany ]:
2

[ RTECS ]:
HY4025000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2921300090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Cyclohexanol
  • N-Cyclohexylcyclohexylideneamine
  • N,N-dicyclohexyl-4-methylbenzenesulfonamide
  • Cyclohexanone
  • Cyclohexylamine
  • nitrobenzene
  • Diphenylamine
  • N,N-dicyclohexylmethanesulfonamide

DownStream

  • 5-[(4-nitrophenyl)methoxy]-4,5-dioxopentanoate
  • 3-Thiophenecarbonyl chloride
  • Z-Leu-OH.DCHA
  • Boc-His(Boc)-OH DCHA
  • 2-Furoyl chloride
  • lithium,dicyclohexylazanide
  • Diphenylmethane
  • Benzene,1-methyl-4-[(4-methylphenyl)methyl]-
  • 4,4'-di-tert-butyldiphenylmethane
  • N,N-DICYCLOHEXYL-2 BENZOTHIAZOLE SULFENAMIDE

Customs

[ HS Code ]: 2921300090

[ Summary ]:
2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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Related Compounds

  • 3-(2-methylpropanesulfonyl)-N-(thiophen-2-yl)piperidine-1-carboxamide
  • N-(diphenylmethyl)-3-(2-methylpropanesulfonyl)piperidine-1-carboxamide
  • 1-(2,6-Difluorobenzenesulfonyl)-3-(2-methylpropanesulfonyl)piperidine
  • 1-(3-Chloro-4-fluorobenzenesulfonyl)-3-(2-methylpropanesulfonyl)piperidine
  • 1-[(3,5-Difluorophenyl)methanesulfonyl]-3-(2-methylpropanesulfonyl)piperidine
  • 1-{4-Methoxy-[1,4'-bipiperidine]-1'-yl}-5-phenylpentane-1,5-dione
  • 1-(1,3-benzoxazol-2-yl)-N-(5-butyl-1,3,4-thiadiazol-2-yl)pyrrolidine-2-carboxamide
  • 1-(1,3-benzoxazol-2-yl)-N-(cyclopropylmethyl)pyrrolidine-2-carboxamide
  • 1-(1,3-benzoxazol-2-yl)-N-[4-(benzyloxy)phenyl]pyrrolidine-2-carboxamide
  • 2-{2-[4-(Pyrimidin-2-yl)piperazine-1-carbonyl]pyrrolidin-1-yl}-1,3-benzoxazole
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