phenylurethane

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Names

[ CAS No. ]:
101-99-5

[ Name ]:
phenylurethane

[Synonym ]:
Phenylurethane
Euphorin
MFCD00026806
ethoxycarbonylamino benzene
phenylcarbamic acid ethyl ester
Keimstop
Ethyl carbanilate
Phenylurethan
N-Phenylurethane
Ethyl phenylcarbamate
phenyl carbamate ethyl ester
Carbanilic acid,ethyl ester
EINECS 202-995-9
N-phenyl-carbamic acid-ethyl ester

Chemical & Physical Properties

[ Density]:
1,106 g/cm3

[ Boiling Point ]:
237 °C

[ Melting Point ]:
47-51 °C

[ Molecular Formula ]:
C₉H₁₁NO₂

[ Molecular Weight ]:
165.18900

[ Flash Point ]:
237°C

[ Exact Mass ]:
165.07900

[ PSA ]:
38.33000

[ LogP ]:
2.32800

[ Vapour Pressure ]:
0.0434mmHg at 25°C

[ Index of Refraction ]:
1.5375

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD8925000

CHEMICAL NAME :: Carbanilic acid, ethyl ester

CAS REGISTRY NUMBER :: 101-99-5

BEILSTEIN REFERENCE NO. :: 1942785

LAST UPDATED :: 199710

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C9-H11-N-O2

MOLECULAR WEIGHT :: 165.21

WISWESSER LINE NOTATION :: 2OVMR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation

REFERENCE :: BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,142,1952

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,45,1959

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity)

REFERENCE :: HDTU** "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 Volume(issue)/page/year: -,-,1933

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59 Volume(issue)/page/year: 5,45,1959 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/kg/2W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 9,177,1955

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 72 gm/kg/15W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

REFERENCE :: BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 10,363,1956

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S36/37

[ RTECS ]:
FD8925000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Ethanol
carbon monoxide
Benzamide
1,3-Diphenylurea
Ethyl carbonate
EthoxycarbonylMethylzinc broMide
Phenylisocyanate
Carbon dioxide
Ethyl iodide

DownStream

1,3-Diazetidine-2,4-dione,1,3-diphenyl-
Hydrazinecarboxamide,N-phenyl-
Sodium 2-Nitroaniline-4-sulfonate
Carbamic acid,N-[4-(chlorosulfonyl)phenyl]-, ethyl ester
Urea,N-(3-nitrophenyl)-N'-phenyl-
Phenyl isothiocyanate
Phenylisocyanate
Ethanol
Benzoic acid,2-[[(phenylamino)carbonyl]amino]-, methyl ester
ethyl N-(4-nitrosophenyl)carbamate

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

Butylphenylurethane
Ethyl phenylurethane
Propyl phenylurethane
Methyl phenylurethane
Methyl N-phenylurethane
phenyl-N-phenylurethane
3-(1-methyl-1H-1,2,3-triazol-4-yl)-2,6-Piperidinedione
3-(5-Amino-1-oxo-2(1h)-isoquinolinyl)-2,6-piperidinedione
3-[(4-bromophenyl)hydroxymethyl]-2,6-Piperidinedione
2-(2,6-dioxopiperidin-3-yl)-4-[({1-[(1,2-oxazol-5-yl)methyl]-1H-1,2,3-triazol-4-yl}methyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-4-({[1-(pyridin-3-yl)-1H-1,2,3-triazol-4-yl]methyl}amino)-2,3-dihydro-1H-isoindole-1,3-dione
3-(8-amino-4-oxo-3(4H)-quinazolinyl)-2,6-Piperidinedione
Benzyl 3-hydroxy-2,6-dioxopiperidine-3-carboxylate
Tert-butyl 3-(4-(bromomethyl)phenyl)-2,6-dioxopiperidine-1-carboxylate
3-(6-methoxy-2-pyridinyl)-2,6-Piperidinedione
Tert-butyl 3-(4-bromophenyl)-2,6-dioxopiperidine-1-carboxylate

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