microcystin yr

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Names

[ Name ]:
microcystin yr

[Synonym ]:
microcystin yr
MFCD00236437
(5R,8S,11R,12R,15S,18S,19S,22R)-15-{3-[(Diaminomethylene)amino]propyl}-8-(4-hydroxybenzyl)-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-1,3-heptadien-1-yl]-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptaazacyclopentacosane-11,22-dicarboxylic acid
1,4,7,10,14,17,21-Heptaazacyclopentacosane-11,22-dicarboxylic acid, 15-[3-[(diaminomethylene)amino]propyl]-8-[(4-hydroxyphenyl)methyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenyl-1,3-heptadien-1-yl]-1,5,12,19-tetramethyl-2-methylene-3,6,9,13,16,20,25-heptaoxo-, (5R,8S,11R,12R,15S,18S,19S,22R)-

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₅₂H₇₂N₁₀O₁₃

[ Molecular Weight ]:
1045.187

[ Flash Point ]:
11 °C

[ Exact Mass ]:
1044.528076

[ PSA ]:
360.87000

[ LogP ]:
-1.85

[ Index of Refraction ]:
1.615

[ Storage condition ]:
−20°C

[ Water Solubility ]:
methanol: 2 mg/mL (further dilute to 10% (v/v) methanol)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H315-H317-H319-H330-H335

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P302 + P350

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+: Very toxic;

[ Risk Phrases ]:
R26/27/28

[ Safety Phrases ]:
26-36/37/39-45-36/37-16

[ RIDADR ]:
UN 2811 6.1/PG 1

[ WGK Germany ]:
3

[ RTECS ]:
000000030272

[ Hazard Class ]:
3，6.1

Articles

Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts--indications of novel tumor-promoting cyanotoxins?

Toxicon 55(1) , 126-34, (2010)

Toxicity and liver tumor promotion of cyanotoxins microcystins have been extensively studied. However, recent studies document that other metabolites present in the complex cyanobacterial water blooms...

Highly sensitive detection and discrimination of LR and YR microcystins based on protein phosphatases and an artificial neural network.

Anal. Bioanal. Chem 404(3) , 711-20, (2012)

The inhibition characteristics of three different protein phosphatases by three microcystin (MC) variants--LR, YR, and RR--were studied. The corresponding K (I) for each enzyme-MC couple was calculate...

Comparison of the toxicity induced by microcystin-RR and microcystin-YR in differentiated and undifferentiated Caco-2 cells.

Toxicon 24 , 161-169, (2009)

Cyanobacterial toxins, especially microcystins (MCs), are found in eutrophized waters throughout the world. Acute poisonings on animals and humans have been reported following MC exposure. Around 80 M...

Microcystin RR
microcystin YM
microcystin LL
Microcystin-LR
Microcystin-WR
(5R,8S,11R,15R,18S,19S,22R)-15-[3-(diaminomethylideneamino)propyl]-18-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,5,8,12,19-pentamethyl-2-methylidene-3,6,9,13,16,20,25-heptaoxo-1,4,7,10,14,17,21-heptazacyclopentacosane-11,22-dicarbox
2-(5-Bromo-2-fluorophenyl)-1,1-difluoropropan-2-amine
4-Amino-4-(5-bromopyrimidin-2-yl)-1lambda6-thiane-1,1-dione
3-Amino-5-bromo-1-[(2-methylpropoxy)methyl]-1,4-dihydropyridin-4-one
4-bromo-1-({2-oxabicyclo[2.1.1]hexan-1-yl}methyl)-1H-pyrazol-3-amine
4-bromo-1-(4,4,4-trifluoro-2-methylbutyl)-1H-pyrazol-3-amine
6'-Bromo-1',2'-dihydrospiro[azetidine-3,4'-[3,1]benzoxazine]-2'-one
4-Chloro-5-fluoro-2-methyl-6-[4-(2-methylpropyl)piperazin-1-yl]pyrimidine
3-(4-Bromo-1,2-thiazol-5-yl)-4-ethylcyclohexan-1-one
3-amino-2-[1-(2-methylpropyl)-1H-pyrazol-4-yl]propanoic acid
7-Bromo-2-(cyclobutylmethyl)quinazolin-4-amine

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