(S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate

Suppliers

Names

[ Name ]:
(S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate

[Synonym ]:
(S)-1-N-Boc-3-Hydroxypyrrolidine
(S)-1-Boc-3-Hydroxypyrrolidine
(S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
(R)-Boc-3-hydroxypyrrolidine
tert-Butyl-(3R)-3-hydroxypyrrolidin-1-carboxylat
(S)-(+)-N-BOC-3-pyrrolidinol
(R)-1-Boc-3-hydroxy-pyrrolidine
1-Pyrrolidinecarboxylic acid, 3-hydroxy-, 1,1-dimethylethyl ester, (3R)-
(S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate
N-t-BOC-(R)-3-Hydroxypyrrolidine
(S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol
(S)-1-Boc-3
tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate
(S)-1-Boc-3-pyrrolidinol
MFCD01317839
N-BOC-3-hydroxypyrrolidine
2-Methyl-2-propanyl (3R)-3-hydroxy-1-pyrrolidinecarboxylate
tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
273.3±33.0 °C at 760 mmHg

[ Melting Point ]:
60-64 °C(lit.)

[ Molecular Formula ]:
C₉H₁₇NO₃

[ Molecular Weight ]:
187.24

[ Flash Point ]:
119.1±25.4 °C

[ Exact Mass ]:
187.120850

[ PSA ]:
49.77000

[ LogP ]:
-0.08

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.502

[ Storage condition ]:
2~8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H318-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic

[ Risk Phrases ]:
R25;R37/38;R41

[ Safety Phrases ]:
S26-S39-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ Hazard Class ]:
6.1

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Di-tert-butyl dicarbonate
N-Benzyl-(3S)-hydroxysuccinimide

DownStream

(R)-1-Boc-3-Fluoropyrrolidine
(R)-tert-Butyl 3-((methylsulfonyl)oxy)pyrrolidine-1-carboxylate
(R)-tert-Butyl 3-(tosyloxy)pyrrolidine-1-carboxylate
tert-butyl 3-acetoxypyrrolidine-1-carboxylate
N-Boc-3-pyrrolidinone
(R)-1-Boc-3-cyanopyrrolidine
(S)-1-Boc-3-(Aminomethyl)pyrrolidine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.

J. Med. Chem. 46 , 4543, (2003)

Isophthalic acid bis(l-prolyl-pyrrolidine) amide is a very potent prolyl oligopeptidase inhibitor, but it has a log P value of -0.2, which is very low for a compound targeted to the brain. Therefore, ...

(S)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate
(S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate
(R)-1-Boc-3-hydroxypyrrolidine
(S)-tert-Butyl 3-bromopiperidine-1-carboxylate
(S)-TERT-BUTYL 3-CARBAMOYLPIPERAZINE-1-CARBOXYLATE
(S)-TERT-BUTYL 3-CYANOPIPERAZINE-1-CARBOXYLATE
(1R,3S,5R)-2-[(prop-2-en-1-yloxy)carbonyl]-2-azabicyclo[3.1.0]hexane-3-carboxylic acid
2-[(But-2-yn-1-yl)[(prop-2-en-1-yloxy)carbonyl]amino]acetic acid
benzyl N-[5-(4-iodophenyl)-1H-pyrazol-3-yl]carbamate
(1S,4S)-4-{[(prop-2-en-1-yloxy)carbonyl]amino}cyclopent-2-ene-1-carboxylic acid
(1R,4S,5S)-2-[(prop-2-en-1-yloxy)carbonyl]-2-azabicyclo[2.1.1]hexane-5-carboxylic acid
2-(3-acetamido-5-methyl-1H-pyrazol-1-yl)propanoic acid
Ethyl 5-amino-2-(azetidin-3-yl)-1,3-oxazole-4-carboxylate
4-acetamido-2-(1H-pyrazol-4-yl)butanoic acid
1-[4-(5-Hydroxy-1,2,4-oxadiazol-3-yl)piperidin-1-yl]ethan-1-one
tert-butyl N-[(2-aminoethyl)sulfamoyl]-N-(propan-2-yl)carbamate

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