Mitomycin D

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Names

[ CAS No. ]:
10169-34-3

[ Name ]:
Mitomycin D

[Synonym ]:
(1aS,8R,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione

Chemical & Physical Properties

[ Density]:
1.64g/cm3

[ Boiling Point ]:
601.7ºC at 760mmHg

[ Molecular Formula ]:
C15H18N4O5

[ Molecular Weight ]:
334.32700

[ Flash Point ]:
317.7ºC

[ Exact Mass ]:
334.12800

[ PSA ]:
138.96000

[ Vapour Pressure ]:
5.47E-17mmHg at 25°C

[ Index of Refraction ]:
1.723

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CN0726000
CAS REGISTRY NUMBER :
10169-34-3
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H18-N4-O5
MOLECULAR WEIGHT :
334.37
WISWESSER LINE NOTATION :
T D3 B556 BN EN JV MVTTT&J E1 GQ H1OVZ KZ L1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
430 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 36,1461,1993
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 20,72,1967

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • MITOMYCIN B
  • 10-O-decarbamoylmitomycin D

DownStream

  • 7-amino-10-decarbamoyloxy-9-dehydro-7-demethoxymitomycin B

Related Compounds

  • 9-Epimitomycin D
  • 9-epi-mitomycin D
  • 7-N-Dimethylaminomethylenemitomycin D
  • 9-epi-7-N-Dimethylaminomethylenemitomycin D
  • 7-N,N(sup 10)-Bis(dimethylaminomethylene)mitomycin D
  • 9-epi-10-O-decarbamoyl-10-O-(phenoxycarbonyl)mitomycin D
  • 2-(1,2,3,4-Tetrahydronaphthalen-1-yloxy)pyrimidine
  • Manganese yttrium oxide (Mn2YO5)
  • 2-[4-methyl-3-(4-methylphenyl)-2,5-dioxoimidazolidin-1-yl]-N-(4-nitrophenyl)acetamide
  • 5,6-bis(4-chlorophenyl)-3-(N-(2-hydroxy-1-methylethyl)carbamoyl)pyrazine-2-carboxylic acid tert-butylester
  • (2E)-3-(3-chloropyridin-2-yl)prop-2-enoic acid
  • 5-Methylbenzo[b]thiophen-2(3H)-one
  • 5,6-dimethyl-1H,2H,3H,4H,7H-pyrrolo[2,3-d]pyrimidine-2,4-dione
  • 2-chloro-N-(2,6-dimethylphenyl)-N-ethylacetamide
  • 2-amino-N-(2,6-dimethylphenyl)-N-(propan-2-yl)acetamide
  • methyl N-[4-(3,4-dichlorophenyl)-4-phenylbutanoyl]carbamate
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