5-[(4-methylpiperazin-1-yl)methyl]-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one

Names

[ CAS No. ]:
101932-30-3

[ Name ]:
5-[(4-methylpiperazin-1-yl)methyl]-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one

[Synonym ]:
5-<4-Methyl-piperazinomethyl>-3-<5-nitro-furfurylidenamino>-oxazolid-2-on
5-(4-Methyl-1-piperazinylmethyl)-3-((5-nitro-2-furfurylidene)amino)-2-oxazolidinone
PM 337
5-(4-methyl-piperazin-1-ylmethyl)-3-(5-nitro-furan-2-ylmethyleneamino)-oxazolidin-2-one
2-Oxazolidinone,5-((4-methyl-1-piperazinyl)methyl)-3-((5-nitro-2-furfurylidene)amino)

Chemical & Physical Properties

[ Density]:
1.504g/cm3

[ Boiling Point ]:
466.769ºC at 760 mmHg

[ Molecular Formula ]:
C14H19N5O5

[ Molecular Weight ]:
337.33100

[ Flash Point ]:
236.094ºC

[ Exact Mass ]:
337.13900

[ PSA ]:
107.34000

[ LogP ]:
0.92680

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.667

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RQ3580000
CHEMICAL NAME :
2-Oxazolidinone, 5-((4-methyl-1-piperazinyl)methyl)-3-((5-nitro-2-furf urylidene)amino)-
CAS REGISTRY NUMBER :
101932-30-3
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H19-N5-O5
MOLECULAR WEIGHT :
337.38
WISWESSER LINE NOTATION :
T6N DNTJ A1 D1- DT5NVOTJ ANU1- BT5OJ ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 19,269,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
450 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 19,269,1964

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-methyl-4-(oxiran-2-ylmethyl)piperazine
  • 5-Nitrofuraldehyde
  • 2-(((chloromethyl)thio)methyl)benzonitrile

DownStream

Related Compounds

  • (2-Chloro-6-fluoro-3-(methoxymethoxy)phenyl)(methyl)sulfane
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-((N-Methyl-2-phenyl-1H-benzo[d]imidazole)-5-sulfonamido)-N-(4-methylbenzyl)acetamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 3-({3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-1-methyl-1H-pyrazol-5-yl}formamido)-2-methoxypropanoic acid
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 2-(Methylsulfanyl)-4-(2,2,2-trifluoroacetamido)-1,3-thiazole-5-carboxylic acid