Phenylbiguanide

Names

[ CAS No. ]:
102-02-3

[ Name ]:
Phenylbiguanide

[Synonym ]:
N-Phenyliminodicarbonimidic Diamide
Phenylbiguanide
MFCD00179077
1-(diaminomethylidene)-2-phenylguanidine
EINECS 202-998-5

Chemical & Physical Properties

[ Density]:
1.33g/cm3

[ Boiling Point ]:
388.4ºC at 760mmHg

[ Melting Point ]:
135-142 °C(lit.)

[ Molecular Formula ]:
C₈H₁₁N₅

[ Molecular Weight ]:
177.20600

[ Flash Point ]:
188.7ºC

[ Exact Mass ]:
177.10100

[ PSA ]:
100.28000

[ LogP ]:
1.88000

[ Vapour Pressure ]:
3.08E-06mmHg at 25°C

[ Index of Refraction ]:
1.656

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DU2450000

CHEMICAL NAME :: Biguanide, 1-phenyl-

CAS REGISTRY NUMBER :: 102-02-3

LAST UPDATED :: 198505

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C8-H11-N5

MOLECULAR WEIGHT :: 177.24

WISWESSER LINE NOTATION :: MUYZMYUM&MR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 16,267,1967

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DU2450000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

amidinourea
1,4-Benzoquinone
4-amino-6-anilino-1H-[1,3,5]triazin-2-one
1,3,5-TRIAZINE-2,4-DIAMINE, N2-PHENYL-6-(TRICHLOROMETHYL)-
2-N-phenyl-6-propyl-1,3,5-triazine-2,4-diamine
1,3,5-TRIAZINE-2,4-DIAMINE, 6-(DICHLOROMETHYL)-N2-PHENYL-
N-(6-Methyl-4-oxo-1,4-dihydropyrimidin-2-yl)-N'-phenylguanidine
1-(4-amino-6-anilino-[1,3,5]triazin-2-yl)-propan-2-one
1-(4,6-DIMETHYL-2-PYRIMIDINYL)-3-PHENYLGUANIDINE
1,3-Diphenylguanidine

Articles

Cardiovascular afferents cause the release of 5-HT in the nucleus tractus solitarii; this release is regulated by the low- (PMAT) not the high-affinity transporter (SERT).

J. Physiol. 593(7) , 1715-29, (2015)

The nucleus tractus solitarii (NTS) integrates inputs from cardiovascular afferents and thus is crucial for cardiovascular homeostasis. These afferents primarily release glutamate, although 5-HT has a...

Microvascular dilation evoked by chemical stimulation of C-fibers in rats.

J. Appl. Physiol. 118(1) , 55-60, (2015)

Activation of pulmonary C-fibers can reflexively decrease heart rate, blood pressure, and peripheral vascular resistance. However, the effects of these afferents on microvascular tone remain incomplet...

5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats.

Vascul. Pharmacol. 72 , 172-80, (2015)

Although serotonin has been shown to inhibit peripheral sympathetic outflow, serotonin regulation on renal sympathetic outflow has not yet been elucidated. This study investigated which 5-HT receptor ...